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10.1006/meth.2001.1262 Methods 73 LongM.DeutschM

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Die Strung dieses Gleichgewichts kann verschiedene Ursachen haben: Eine zu hohe Produktion toxischer Spezies aufgrund von Stress, ein Nahrungsmangel an exogenen Antioxidantien, ein Versagen der internen Abwehrsysteme oder die zustzliche Exposition gegenber toxischen Spezies (Zigarettenrauch, Alkohol, Umweltverschmutzung, usw.) Sobald dieser oxidative Stress lnger andauert, kann er dramatische Folgen fr alle Hauptbestandteile des Organismus haben - Zellen, Fettsuren, Proteine (wie DNA), Zucker - und zur Entstehung bestimmter chronischer Strungen beitragen (1-2)

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D-2-hydroxyglutarate is necessary and sufficient for isocitrate dehydrogenase 1 mutant-induced MIR148A Promoter Methylation

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